The only issue I have is I double click an Excel file, it takes several minutes for the file to come up.
I have found that when I open Excel and if I right-click, click Open and then click Cancel, it brings the document quickly.
If you have Acrobat 5 installed, do a search for PDFmaker.xla on entire c: drive. Whatever you find in Office startup folders delete.
You can still use Acrobat Distiler to create PDF files or use the built-in function from Excel : “Save As”.
If still doesn’t work try activating one “Add-in” from Excel and it should do the job (I have no explanation for this, it just works).